I shoot the 55gr Sierra GameKing BTHP from my Remy 700VS. I use 40gr of H380 with Match Primers. Shoots great groups however I have also shot the factory 55gr Sierra Gamekings and 55gr Federal HiShok softpoints. I did not have an accuracy problem with any of them and they all killed chucks fine. I reload only because its cheaper than buying factory premium bullets and it gives me something to do over the winter. Good Luck.
PJ3

38 of H38
 

I have been working on a load for my custom 22/250 for five years. I was aware of the 38.0 grains of H380 but ignored it thinking I will find a new better recipe of my own. Now five years later and still no bragging rights I tried this load w/ a 50 grain V-max.............. one hole groups!!!!!!!!!!!!!!!!

Hey BAN, welcome to the Hood. I've got a pound of H380, maybe I'll try that combo also.
Allen

Much is going to depend on your rifles barrel twist. Most rifles in .22-250 have a 1 in 14" twist and will do a nice job with 55gr. and lighter bullets. Anything heavier is iffy. Faster twists to about 1 in 9" will allow accuracy with the heavier bullets. Even so,
more goes into it than that. You have to conside the bullet type, length and configuration into the equation. The .22-250 is one of my favorite calibers, but I have to be mindful of its limitations. Best wishes.

Cal - Montreal

With the Nosler 50gr. Bal Tip I use IMR4064 35.8gr. It gives me a velocity of 3700fps and prints groups of .286" (5 at 100yds).

With the Nosler 55gr. Bal Tip I use IMR4064 35.2gr. It gives me a
velocity of 3500fps and prints groups of .266" (5 at 100yds).

There are many bullet and powder combinations that work well in this caliber. It's quite versatile. Best wishes.

Cal - Montreal

With the Nosler 50gr. Bal Tip I use IMR4064 35.8gr. It gives me a velocity of 3700fps and prints groups of .286" (5 at 100yds).

With the Nosler 55gr. Bal Tip I use IMR4064 35.2gr. It gives me a
velocity of 3500fps and prints groups of .266" (5 at 100yds).

There are many bullet and powder combinations that work well in this caliber. It's quite versatile. Best wishes.

Cal - Montreal

For those times you're shooting from the bench you'd do well with the Sierra 52gr. HPBT and the Berger 52gr. HP. I wouldn't use them for anything larger than woodchuck though. The 55gr.
bullet is a better choice for game taking. Best wishes.

Cal - Montreal

While the Nosler Bal. Tips in 50 and 55grs. are a favorite of mine I wouldn't neglect some of the others, mainly the 52 grainers. Although not sold as hunting bullets the Sierras 52gr. HPBTs are very accurate as are the Berger 52grs. HPs and will really do a number on small game like woodchuck. There are a lot of excellent bullets available to us in 50, 52 and 55grs. for the .22-250. Best wishes.

Cal - Montreal