I agree that wind is the big problem with long range shooting.
I shoot a lot of woodchucks during the summer. I set up a table in a likely field, and use a rest, and rear sandbag. For the long shots I use a rifle that's zeroed for 400 yards.
A rangefinder will tell you the range, and you can run trajectory charts that will tell you the hold over, down to the last half inch. You can dial in the elevation on the scope adjustments if you want to, so that you're exactly on point of aim, no matter what the range.
However, the wind is much more difficult. Is that a 10 mph wind? Or is it 17 mph? Is it steady, or is it gusting?
And, is it doing the same thing where the target is that it's doing where you are?
Shooting a high BC bullet that resists wind drift well helps, but wind is still the toughest factor.
Last summer I hit one woodchuck by holding 37 inches into the wind! I'd never try that on a game animal.