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I have been shooting a .338 Remington Ultra Mag for deer and elk. If sighted in 4" high at 100 yards the point blank range is around 285 yards. A 250 grain swift A-frame bullet is down about 11" at 400 yards. Foot-pound of enegry does not drop below 2000 until almost 350 yards!
With reasonable optics, my guns effective range is about 380 yards. It is however, not for the faint of heart or the slight of build, because it does pack a whallop!