I saw two hogs that weighed 300+ shot with the 44mag. One was shot with the Federal premium 300gr castcore bullet and the other was shot with a handloaded 240gr XTP. Both of them kicked the crap out of those beasts. The XTP left some nasty holes. Range was 30-45yds. 44mag will do the job.
I shot a 325lb boar with my 454 Casull. A handloaded 300gr Swift A-Frame bullet was shot through the thickest part of his grizzle plate. Distance was 43 yards. Not only did the bullet easily penetrate the plate, it blasted right out through the opposite side. Boar left a 3 foot wide blood trail for about 40yards. Ol' porky makes for a nasty mount in my office.