FailSafes are excellent bullets. They may be more than you need for most game, but where they're really needed, they excel.
Answer this: if you need extreme penetration on very large and tough game - or dangerous game - then you might need an expensive and exotic bullet like the FailSafe.
If you're hunting deer, antelope and such the Failsafe will certainly work. But it's like buying a Ferrari to haul kids to school. You can get a perfectly adequate bullet for deer without needing a second mortgage. Barnes X, Partitions or bonded bullets are cheaper while being plenty tough enough for that 300 maggie.
That goes for the 140 Noslers in the 270, too. Perfect.
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