Now if your speaking of Kudu, Wildebeast or Eland, I prefer the .338 win mag hands down. I have seen the results first hand with people using a 270 on such animals. Looking for wounded animals is no fun on a limited number of days hunt and not to mention writing the check for that animal if not found.
I think Impala, gembok and smaller are fine for such calibers as the 270 and 7mm's. I favor the heavy bullets in the .30 calibers everytime out the gate. The 180 or 200 grainers in a premium bullet as well.