Ruddyduck............I would still opt for the .458 Win mag, you can have that rechambered out to the .458-LOTT and I know darn well it will loosen up any ideas PH's have about it NOT having enough velocity of Smack Down Power to handle anything in Africa OK. The cost of rechambering to the Lott caliber runs around $125 dollars US money!
Years ago it was the "WATTS" caliber which took front stage, to fix the matter of Slooooow .458 Win mag rifles. Only you could not fire standard .458 Win mag ammo in that rechambering as you can the LOTT.
BrithHunter!......... My .375 Weatherby is in fact a "Model 70 Winchester" to begin with and had the chamber opened up just a smiggin. It also shoots standard .375 H&H ammo as well. There is nothing wrong with a .375 Weatherby caliber, one of the best ever to have hunted big game in Africa.