[fabsroman]

This is almost like trying to pick the best deer cartridge and that thread got pretty long and pretty heated.

For varmints I have a .22 lr, a .222 Rem, and a .220 Swift. As Dom said, it pretty much depends on the range you are shooting at. The .22 lr. is good to about 50, maybe 75 yards. The .222 Rem is good to about 200, maybe 250 yards. The .220 Swift is good for a long ways unless it happens to be very windy. I also have a .270, .30-06, and .300 Win, but I don't use any of those three for varmints. The next rifle I buy will probably be a .25-06 for those really long range shots on varmints and those shorter range shots on deer.

Which gun I take out of the cabinet/safe on any given day depends on what the day is like (e.g., wind), what the ranges will be, and what the quarry will be. It is tough to just select one cartridge/shotshell for all my hunting when there are so many different ones out there. Same goes for guns and optics, and don't even get me started on hunting and fishing gear.

Kind of like asking which bait is the best for Rockfish. The answer is whatever they happen to like the day you are fishing.