Billy. Life with a Ruger #1 is like life living with a woman, you never know till you live with her.
Guess I must be a polygamist as I have 16 of these rifles plus a custom job built on a #1 action. They range from a #1B in .22 Hornet to a #1H in .416 Rigby, plus a #1H in 45-70.
Some can be very temperamental like a prima donna and other just like a faithful hound dog.
You didn't say whether you were looking at a #1B or 1V. You'd probably get better accuracy from a #1V than the B, but most seem to shoot reasonably well. I've only had one that was bad enough to have to send back to Ruger for repairs and they put a whole new barrel on that one.
It all depends on just how much accuracy you feel you need. I've seen #1s deliver .375" groups. My .300 Win. Mag. 1B is consistantly doing this. My .22 Hornet will put ten rounds inside a dime with factory ammo. My #1v is another tackdrive in .223. Most of the rifles for big game shoot groups comeasurate with the game they're designed for, and mostly better than that. Some were good out of the box and some had to be tinkered with. The custom job, a #1 action with Remington .223 lightweight barrel and custon stock has had to be seriously messed with and still needs tweaking.
I can't say I know all the answers to making one shoot good, but if you decide to comit to that 22-250 and do have problems, I'll be more than glad to try and help out.
Like I said, living with a #1 can make life interesting. I wouldn't have it any other way.
Paul B.