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Man, those are all excellent caliber choices. 22-250, 308, 25-06, 223, can't go wrong with them. I love every single one of those calibers, so whichever you like is going to do the trick. I've used 223 out to 800 yards on pdogs, but a 22-250 may be the better gun to reach out to beyond 1000 yards effectively, even on bigger varmints like coyotes. 25-06 and 308: more price to pay for varmints than I'm willing to give for the ammunition(I do a lot of shooting when I get started), but the 25-06 has a more desirable trajectory so being off a little on range won't hurt like it will on the 308, and some solid energy at long ranges will do the trick on any varmint in an instant. The 308 would be my choice out of the 2 bigger calibers, for price, and popularity.
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I like to shoot stuff.
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