You'll find drum-thumpers for both (and I own several 45 Colts but no 44 Mags) but in reality it's a coin toss.
There's a lot more mild ammo available for daily use of the 45, and more full-bore ammo on shelves for the 44. But there are loads at both ends for both.
Effect on critters is exactly the same: a big red pool and quick assumption of room temperature. With a wrist "owie" at the other end.
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