Get a Thompson Center Contender or an Encore. The Encore is chambered in regular rifle rounds but the contender is chambered in real hunting handgun rounds. I have a 14 in 44 mag and a 14 in 35 Rem 14 in 357 Rem Max and 223 bbls. They all seem to work great. The 35 is a good deer hunting round...Someone told me the 357 Rem Max is just as good if not better.
I also have a Rem XP 100 in 35 Remington. One of the silhouette guns...but I've never shot it.