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Pomoxis is right about the CZ being a little rough. I mentioned it only because, if you picked the Rigby cartridge, which requires a true magnum length action, these rifles are by far the cheapest way to go. Even with a few hundred spent at the local gunsmith to smooth up the action (Oh, and I would also have the bolt handle shape altered, it lays a little too close to the stock.) you will still save a considerable amount of money over the other makes that are available in .416 Rigby. I have owned several of the CZ's in .375, .416 Rigby and .458. They all needed some work, but they were dependable and shot well. If you opt for the Remington or you want the Rigby and money is no object, there are a lot of fine choices out there.
I have shot buffalo with a .375, a .416 and a .458. As pomoxis stated the .375 will do the job. If you do run into some problems then a bigger bullet and larger frontal area is a good thing. More importantly though, is your ability to shoot your rifle well.
I have regressed from the .416's back to a .375. Why? Because I have one that I have been packing for years while guiding. It is a trusted friend and whatever I point it at goes down. I will use it the next time I go for buffalo and if the day ever comes that I can afford an elephant hunt (like winning a lottery............that's the only time my wife would let me drop $50,000 on a hunt) I will be looking towards something like a .458 Lott or .470 Nitro.
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