I have had great luck with sierra 55 gr. spitzer and h 380 at 3443 fps, mild but deadly accurate At 1/4 in X 1/2 " groups are very consist ,I some times I may drop to a 52 gr sierra to pick up some additional velocity but the h 380 is my go to load in my Sako 22-250 varminter.Also 4064 gives good results at 3400 fps as well about 1/2 in X 1/2 ' groups,hope this leads you in the right direction By the way I use only CCI bench rest primers in these loads.