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Yep, I use the Barnes X bullets too out of my .300 Win Mag. Killed two decent whitetail bucks with them, one that dropped in its tracks because I broke its front shoulder and another that ran 50 yards with one in the boiler room. The bullet has worked great on does too.
However, a grizzly is an entirely different animal. I wouldn't want to wound one and then have to chase it into the bush. Heck, I wouldn't want to wound one and have it chase me into the bush.
As far as the recoil of the .375 is concerned, I bet it hits a lot softer than a grizzly mauling you.
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The pond, waterfowl, and yellow labs...it don't get any better.
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