If your worried and I would be about the backlash of a 375 try shoot one before you purchase it. I bet someone at a local range would offer it you.
Me, well I'm a recoil wimp. I would go with a good 338 Win Mag. Pretty much duplicate balistics as a 375 with a little less recoil. I bet there is nothing in Alaska that would walk away from a good 250 gr bullet from a 338. My 2 cents.
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