That bullet is going to be moving mighty fast, and it better be tough to hold together so it can do it's job and hopefully leave you a nice exit hole.
I'd sure lean towards the 180 grain Nosler. Better yet, I'd lean towards one of the bonded premium bullets like a Swift A-Frame or Trophy Bonded Bear Claw. 180 is still a light bullet for a .300 Weatherby, you're friend sure won't miss any difference in the long range trajectory. If I were taking a .300 Weatherby elk hunting I'd use 200 grain bullets. To me, the main advantage of hunting with a magnum is that it lets you shoot heavy bullets at the same trajectory (or maybe better) that a standard cartridge would shoot a lighter bullet. Those heavy, tough bullets can really make a difference punching through an elk, and I think that's worth more than a flatter trajectory with a lighter bullet designed for long range shooting.
Sorry to ramble, if your choice is limited to the bullets you mention, go buy a couple boxes of the partitions in 180 grain and tell your friend what he owes you.
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"Watch your top knot."
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