The first shot is the most important. If you are able to hit the central nervous system a second or third shot for insurance. If you have a heart lung shot you have the shot placement is the next issue. I shot a cape buffalo with a heart lung shot and it ran 85 yards, that was the good news the bad news was that I shot him at 70 yards and he ran 50 yards back at us.
He squared off at 20 yards before running parrell to me allowing for my 5th shot. I was reloading when he squared off. If the bull would not have reacted to the echo of the shot we would have walked up on a dead buffalo. By the way I was using a .375 H&H.
Being over gunned may cause you to flinch and not placing your first shot exactly where you want it. There can be too much of a good thing when you are talking about knock down power.
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