7MAGinPA, I never shot a cougar either.
Are using a 45LongColt or the ACP version?
If you have a 44mag, I'd use that.
But then why not get a new 45LC if you don't have one already.

Personally I'd use my 12ga with a slug or two first followed up with 3" 00-Buck. that might help settle the dust if a cat tries to get close and personal.