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Like toxic yes a 06 is just fine for moose. Your a handloader so a good nosler, barnes or anyother premium bullet will do the trick.
Most local in Newfoundland use 270's, 280's or 06's. They see more moose killed in a week that we do in a lifetime.
Over the last 15 or 20 years the Magunum craze has lead us to believe that big game are immune to standard rounds. No so. Good hunting.
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