I've had a lot of problems with 22's and squirrels (as well as 17's and squirrels)
As long as they are shot in the head, they go right down. The problem I have is when they are shot in the shoulder. Somehow they always run - even with hollowpoints. A lot of the times I can't catch up.
Missouri is fortunate to have the season in May.
So I choose my 20ga mod with high brass 6's and they go right down.
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