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Hey Jon,
I've used my 22WMR on yotes, but only from a stand at close range 25-60 yards.
Use heads shots, if you cant get the head, dont take the shot.
You can get some varmit loads for the 30-06 that will work really well, and give you soem decent range.
I actually prefer my .243win, or 8mm for yotes, 8mm would be equivilent to the 30-06 and works _very_ well.
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