barrel twist and bullet weight

[Karl Peterson]

In general, is a heavier wt bullet more accurate in a 14 twist barrel or is a lighter weight better?

Example: In a 22-250, 14 twist barrel would a 40gr bullet have more accuracy or would it be better to go with a 50 55 or 60 wt bullet?

If some one can explain all this to be, I would appreciate the education.
Thanks,
Karl