Perspective on Bullet Performance

[Cossack]

With all the variables to consider (distance, game size, shot angle, etc) I like to think that a premium bullets makes that individual gun all that it can be. For example, the 243 is marginal for large deer. Loaded with conventional bullets (some of which are intended for varmints) it can produce spectacular kills if you hit just right. But there is no margin of error. Loaded with a premium (Barnes TSX for me) at least you don't have to worry about the possible effects of hitting a rib or shoulder; a raking shot is still risky.
So it's still a marginal caliber but just made a bit better for reasonable application. Is the 243 more like a 7/08 or 260 as a result? I'll let you decide.