Shotgun slugs versus muzzle-loaders

[Jack]

The O/U is not considered the best platform to shoot slugs from. Typically the sights aren't very precise, and you may find the O/U shoots one barrel to one point of aim, the other barrel to another.
Now, inside 50 yards, it might not make much difference.
A well set up shotgun, single barrel, with a rifled barrel and good sights, should shoot slugs with sufficient accuracy to be a 100 yard + gun- likely to 150 yards.
A muzzleloader with decent sights should also be effective to 150 yards.
Personally, I would prefer either a muzzleloader or a pump or auto shotgun set up for slugs, to an O/U shotgun for game hunting. I love O/U's, but, IMO, they are bird guns, not deer guns.