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			i do believe muzzleloaders can be 250yd guns. t/c and nikon must agree they made a scope for just that issue.  and knight devoted a gun to 200 + shots.  power belt co.  mentions a light 223 gr bullet for long range. 
i find different issues, i think with these things and low velocity maybe a heavier bullet is a bettter choice for long range.  although a rangefinder would be damn near essential, i smashed a doe a few years back, i am zero'd at 100yds and held over her back to hit the bullseye, makes me really wonder how far that one was.  regardless of bullet expansion, a accurate 50 cal hole is life changing for a deer no matter the distance 
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